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HIV infants studied
Infants infected with HIV who are treated with one or two antiretroviral drugs within two months of birth are less likely to develop AIDS by their third birthdays than infants who are treated later, according to a new study conducted by researchers at Stanford’s School of Medicine and the Lucile Packard Children’s Hospital. Babies who received a cocktail of three antiretroviral drugs fared even better. The results are significant because there is still some uncertainty about potential side effects when drugs are administered at a very young age.
“There is a significant difference in the likelihood of disease progression, even though there is only about a month separating the initiation of therapy in the two groups,” said[censored]ociate Prof. of Pediatrics Yvonne Maldonado, the report’s senior author.

Currently, deciding when to begin treating an HIV-infected infant is the responsibility of the child’s physician, largely because the long-term effects of ongoing retroviral treatment are unknown.

“The whole idea of the study is to follow children with HIV over time and make sure we could track the illness in children, then to use that tracking to make sure we could treat children better and more effectively,” Maldonado said.

Without treatment, about 20 to 30 percent of infected infants will develop AIDS by the time they reach four months old. The rest will develop advanced symptoms by the time they are six years old.

Since some of these infected infants will appear healthy, researchers suggest that early treatment might be appropriate for even those who do not show symptoms of the disease. However, they caution that clinical trials are needed to determine if every infected newborn should be treated or if some infants will benefit more than others.

Maldonado and her colleagues collected data from hospitals throughout northern California over a 17-year period beginning in 1988. They followed the children for the first three years of life, tracked their age when AIDS developed and the rate of survival through their third birthdays.

“We were able to analyze children with the full-spectrum of disease across many years, rather than using mathematical models to predict the development of illness in the children,” Maldonado said. “We were able to see the real distribution of illness, what kinds of treatment the children were given and the ages when they started treatment.”

The researchers divided the newborns into three groups: those born between 1988 and 1991, between 1992 and 1995 and between 1996 and 2001 based on the types of therapy available in those years. Members of the early group were tested for infection by their first birthday; members of the middle and late groups were[censored]essed within the first month, and those in the late group benefited from the introduction of a special type of antiretroviral drug called a protease inhibitor, which interferes with the virus’ ability to replicate.

Not surprisingly, infants born later were more likely to receive triple-drug therapy and less likely to experience symptoms of AIDS. In fact, none of the 23 children who received triple-drug therapy developed AIDS before their third birthdays and none died.

“This is an important finding because there’s been a lot of controversy in the literature as to whether infected but asymptomatic infants should be started on therapy right away,” Maldonado said. “We’ve clearly shown that early treatment of asymptomatic infants — no matter what it is — makes a big difference in preventing or delaying the progression of the disease.”

Posted by LivingPositive on Wednesday May 18 2005 - 15:59:26 | Read/Post Comment: 12 | email to someone printer friendly
Roche says to pull older HIV drug on poor demand
Roche Holding AG said on Wednesday it will voluntarily withdraw its anti-HIV drug Fortovase in early 2006 because demand for the drug has declined significantly.
The Swiss drugmaker said Fortovase will be discontinued in the first quarter of 2006 because of the availability of a new formulation of the drug, sold as Invirase, which is easier to tolerate.

Roche said the decision was not a result of concerns about safety or effectiveness. Roche said its drug Invirase will remain on the market.

Posted by LivingPositive on Wednesday May 18 2005 - 15:51:10 | Read/Post Comment: 14 | email to someone printer friendly
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